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In addition, curcumin is known as a generally recognized as safe substance ( Challenges and limitations Despite its promising therapeutic potential, curcumin exhibits poor aqueous solubility (11 ng/mL), chemical instability at neutral to alkaline pH, and low oral bioavailability due to rapid hepatic metabolism and systemic elimination

Nature 431 , 873878 (2004)

This is vital for those who go straight from the airport to meetings

38 , 21492153.e2141 (2023)

Different explanations can be suggested for the changes in GSSG concentration or GSH/GSSG ratios that are not accompanied by any change in GSH concentration: in mammalian cells, three mechanisms serve to maintain the GSH homeostasis, de novo synthesis, the catalyzed reduction of GSSG, but also an extracellular uptake (retinal GSH may be increased because there is an uptake from other parts of the visual system)