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This study provides a novel perspective and scientific rationale for the clinical management of AD and offers new insights into the development of advanced topical therapies that not only cover the anti-inflammatory effect, but also exhibit interesting antibacterial, antioxidant, and skin barrier restorative properties for the long-term control of this chronic inflammatory dermatosis

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They peak around week 20 of the protocol, which corresponds to the early weeks on the maximum 2.4mg dose

Although strict avoidance remains the primary management strategy, emerging immunotherapeutic approaches such as allergen-specific immunotherapy, hypoallergenic variants, DNA vaccines, and microbiome-based interventions are reshaping future treatment paradigms