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This generates high ROS, LP, and OS levels, ultimately resulting in cell death

PfGrx shares 39% sequence identity with human Grx1, including a CPYC motif and a semiconserved GGC motif, and is well characterized in vitro and in roGFP2 assays in yeast 14,26,30,35

So too is the trace element selenium, a deficit of which causes hepatic haem to be wasted down the bilirubin route (47)

PLoS ONE 5 , e9125 (2010)

Metzger S, Saukko M, Van Che H et al (2010) Age at onset in Huntingtons disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7