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[85] Effectiveness is generally expected to slowly decrease over time

Thioctic acid can be injected directly into a vein using a syringe and perfusor, even with a minimum injection time of 12 minutes

Pangamic acid (vitamin B 15, pangametin, sopangamine): its composition and determination in pharmaceutical dosage forms

Studies show it may be well tolerated in higher doses of 700mg three times a day, as well, with few to no adverse effects when taken as an oral supplement (but we dont recommend taking more than what a supplement manufacturer instructs).31 That's not to say that adverse effects aren't out of the question