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Association of inorganic-pyrophosphatase activity with human alkaline-phosphatase preparations

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These landmark studies showed that mice with adipose-tissue-specific NNMT knockout remained lean when fed high-fat diets that caused wild-type mice to become obese, and that these protected mice had increased energy expenditure, enhanced fatty acid oxidation, improved glucose tolerance, and elevated NAD+ levels in adipose tissue

Clinical Cancer Research , 10 (22), pp.7703-7711

The first injection on the new compound may produce mild differences in side effect profile because of vehicle differences between manufacturers, but these typically settle within 1 to 2 weeks