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For many men on testosterone replacement therapy , this is exactly what the three-to-six-month window feels like, and

IEB Intestinal epithelial barrier GI Gastrointestinal TJs tight junctions IBS irritable bowel syndrome IBD inflammatory bowel diseases MUC2 mucin 2 AJs adherens junctions JAM-A junctional adhesion molecule-A ZO zonula occludens CD celiac disease NCGS non-celiac gluten sensitivity PAR-2 Proteinase-activated receptor 2 SCFAs short-chain fatty acids TLRs Toll-like receptors FGIDs Functional Gastrointestinal Disorders HLAs human leucocyte antigens GFD gluten-free diet UC ulcerative colitis

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To better comprehend the role of an increased intestinal permeability in GI diseases, it is crucial to understand some basic concepts on how different molecules cross the intestinal epithelium and how intestinal permeability can be evaluated in humans