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Pathological characteristics of AD include extracellular A accumulation and the hyperphosphorylated microtubule-associated protein, tau (p-Tau) [218]

Currie E, Schulze A, Zechner R, Walther TC, Farese RV Jr

Folic acid can upregulate DHFR expression and activity, which in turn enhances the regeneration of BH4 from its oxidized form, dihydrobiopterin (BH2) [55, 56]