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Due to this variability in the cholesterol content of LDL particles, the concentration of LDL-C does not accurately reflect the quantity of existing particles (LDL-P), especially in the following situations: Family history of atherosclerotic cardiovascular risk High triglycerides Low levels of HDL cholesterol Metabolic syndrome Diabetes mellitus Recurrent events due to atherosclerotic cardiovascular risk despite lifestyle changes and/or hypolipidemic therapy Hence, a high number of LDL-P can be associated with normal LDL-C concentrations, indicating an excess of small-sized particles with low cholesterol content but high atherogenic potential

Unlike compounds such as vitamin E or beta-carotene, AST readily crosses the bloodbrain barrier and acts across both hydrophilic and lipophilic environments, enabling broad neuroprotective effects

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Ledo et al., 2013)

One of the hallmarks of CIPN is axonal degeneration, which is reproduced in in vitro cellular models in the form of shortened neurite length or reduced neurite branches