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LEfSe is known to reduce false positives and can highlight biological consistency across subclasses, while the KruskalWallis test used alone can achieve a lower false-negative rate compared to LEfSe 38

These changes suggest ARA-290 may influence metabolic function through its anti-inflammatory effects, since chronic inflammation contributes significantly to insulin resistance and dyslipidemia

Preclinical studies have described effects on tendon healing, ligament repair, muscle regeneration, and inflammatory modulation (Vasireddi et al

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