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The authors established FOXO4-DRI as a first-in-class senolytic peptide tool for cellular senescence research, with mechanistic selectivity grounded in the elevated FOXO4-p53 interaction in senescent versus non-senescent cells

Although the silane groups of the C18 column are also fully protonated the acidic environment provides sufficient protons (H + ) in the solution that the acidic NAC will retain its protons, improving retention on RP-HPLC

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B., Strange A., Saarela J., Bellenguez C., Fontaine B., Gillman M., Hemmer B., Gwilliam R., Zipp F., Jayakumar A., Martin R., Leslie S., Hawkins S., Giannoulatou E., et al., Nature 2011, 476, 214.21833088 [Google Scholar] 183