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Additionally, pyridoxine therapy alone does not reduce fasting homocysteine and the reduction in postmethionine-load homocysteine levels was smaller for pyridoxine than for the combined therapy using folic acid and pyridoxine (van der Griend et al, 2000)

There are also rarer risks

233-235 In a randomized controlled trial in 84 subjects with coronary artery disease, 30 mg per day of crocin for eight weeks lowered levels of oxidized LDL and an inflammatory marker (monocyte chemoattractant protein-1, or MCP-1), and inhibited expression of genes related to atherosclerosis compared with placebo

Reverse osmosis systems and carbon filters are even more sensitive, as bacterial slime can foul these products more quickly

Interestingly, crossing Igf2 ko with Igf1 rko resulted in further growth retardation indicating that IGF-II had actions through an additional receptor