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Most current knowledge about the pathogenesis of cataract has come from the study of live animal or in vitro models using animal lenses or lens cells in culture, because intact human cataract tissue has become very difficult to obtain with the advent of phacoemulsification procedures

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The consequent ROS accumulation in the body is inevitably associated with tissue injury [1], since ROS are known to damage cell components, particularly DNA, leading to loss of function, induction of apoptosis, or even carcinogenesis [2]

Intranasal is a separate route option, especially for CNS-focused use

FDA evaluated Epitalon free base and Epitalon acetate for possible inclusion on the section 503A Bulks List