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Similar features have been reported in other microbial species

non-motor symptoms include autonomic dysfunction, sleep disorders, cognitive abnormalities, and constipation, see the reviews by Most PD cases are sporadic and approximately 10% of cases are inherited (Yoo et al., 2018)

Hepatoma cell lines typically lack the CYP450 activity to generate the reactive metabolite of APAP observed in vivo, but are still subject to APAP cytotoxicity