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DNA methylation is the process of adding methyl groups to the fifth carbon of cytidine (C5) or in the N6 position of adenine within the DNA strands, and it is considered the most frequent and stable epigenetic modification associated with silencing of gene transcription [6,7,8]

It works by binding directly to the IGF-1 receptor (IGF-1R) on muscle and other tissue, activating the PI3K/Akt and MAPK signaling cascades that drive cell growth and proliferation

The function of -synuclein

Sources: [1] Benzyl alcohol bacteriostatic preservative properties (NIH PubChem) NCBI

Additionally, accelerated ATP degradation under pathological conditions (e.g., intense exercise and ischemiareperfusion injury) promotes hypoxanthine accumulation, creating a secondary drive for UA overproduction (Uskudar Cansu et al., 2019)