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This cascading event is exacerbated by aging with a declining proteostasis, thereby reducing the cells ability to protect its more vulnerable proteins from coaggregation, eventually resulting in the collapse of essential cellular functions

Superficial fibrin thrombi and other findings: a review of the histopathology of human scabietic infections

doi: 10.1016/j.semcdb.2016.04.009 14 VerzePCaiTLorenzettiS

This involves a network of epigenetic regulators and transcription factors, specifically SIX2, HNF, and TCFAP, located within the methylation areas of DNA (78, 79)