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Chloroplast-mediated activation of plant immune signalling in Arabidopsis

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Sulfur-containing glucosinolates are synthesized from glucose and amino acids, which consists of the -D-thioglucoside group and an N-hydroxyiminosulfate ester, leading to the formation of SFN, whereas myrosinase, an enzyme present in plants, catalyzes a hydrolysis reaction that results in the formation of SFN by joining it with the protein epithiospecifier (ESP) (inactive form)

These therapies display higher efficiency compared to classical senolytic drugs (BCL-2 or tyrosine kinase inhibitors) but for some of them, such as NA + /K + ATPase inhibitors, clinical development could be complex in the light of strong cardiotoxicity associated with this class of molecules

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