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In addition, Myc-dependent expression of ATF4 in DLBCL cells, human colon adenocarcinoma cells, and mouse embryonic fibroblasts drives the expression of SLC1A5 during metabolic adaptation to stress conditions 73,80,81

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Given the key role of oxidative stress in CIO, antioxidants have been used as otoprotective agents in a large number of studies targeting the prevention of cisplatin-induced hearing loss, such as N-acetylcysteine, sodium thiosulfate, amphotericin, vitamins, statins, dexamethasone, D-methionine, and ginkgo biloba extract (Rose et al., 2024)