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Under normal conditions, the bodys antioxidant defense system comprising enzymatic antioxidants like glutathione peroxidase and SOD, along with non-enzymatic antioxidants such as selenium and vitamins C and E neutralizes ROS to maintain cellular balance [34]

Demonstration of spread by Mycobacterium tuberculosis bacilli in A549 epithelial cell monolayers

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Subsequently, during the late 1800s, William Coley used Streptococcus pyogenes infections to regress patients sarcomas, which inaugurated bacterial-mediated microbial therapy ( Streptococcus , Salmonella , Escherichia coli , Clostridium , Bifidobacterium, Listeria , and Lactococcus were effective in anticancer therapy (Yin et al., 2022)