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As of now, clinical trials combining bispecific antibodies with hyaluronidase are in full swing, particularly the star product Rybrevant (amivantamab) from Johnson & Johnson, which is being administered in a fixed subcutaneous combination with recombinant human hyaluronidase

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Koppe T, Patchen B, Cheng A, Bhasin M, Vulpe C, Schwartz RE, Moreno-navarrete JM, Fernandez-real JM, Pissios P, Fraenkel PG (2017) Nicotinamide N -methyltransferase expression decreases in iron overload, exacerbating toxicity in mouse hepatocytes