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223 In a randomized controlled trial in 30 women with fibromyalgia and vitamin D levels below 32 ng/mL, 1,200 IU (30 mcg) or 2,400 IU (60 mcg) of vitamin D3 daily, depending on baseline levels, for 20 weeks led to marked reduction in symptom severity and improved physical function compared with placebo

Mental health: Irregular circadian rhythms can increase symptoms of anxiety, depression, and other mental health conditions

From a neuroscience standpoint, the brain is relearning how to regulate stress without chemical assistance

A 5-tier scoring paradigm was used to assess toe spread function: score 0no visible toe spread