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Furthermore, magnesium sulfate was effective as a treatment for preeclampsia, significantly promoting GSH production and suppressing ROS generation (Kawasaki et al., 2019

Oxidative stress from environmental pollutants

Although the heavy subunit by itself can catalyze the formation of L--glutamyl-L-cysteine, binding with the modifier subunit enhances the enzyme activity by lowering the Km for glutamate and ATP, and increasing the Ki for GSH inhibition