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Trophoblasts, in the process of connecting with maternal blood vessels, accelerate villi formation while expanding their surface area, which leads to increased intervillous space perfusion: OS levels are thus increased, triggering the expression of heat shock protein (hsp60 and hsp70), which results in retardation of fetal development and possible pregnancy failure [36]

Additional studies also report that chronic inflammation impairs key intracellular signaling cascades, such as PI3K/Akt and mTOR, in granulosa cells, thereby promoting ROS accumulation and impairing follicular maturation (Gonnella et al., 2022)

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