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Parkin/PINK1-mediated mitophagy Mechanisms of Parkin/PINK1-mediated mitophagy Mutations in PINK1 (a serine/threonine kinase) 21 and Parkin (an E3 ubiquitin ligase) 22 are the most common causes of recessive forms of PD

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10.1254/jphs.91.71 124 IslamM

457 Disturbances in BCAA metabolism also play a critical role, with elevated BCAA levels detected in failing hearts, likely due to impaired BCAA oxidation during heart failure

Vascular elements on hematoxylin and eosin stained slides as well as immunohistocemically positive elements were examined in a blinded fashion using hot-spot assessment and ISSA program (VAMSTEC, Zagreb, Croatia)