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Key gaps include: No large-scale randomised controlled trials in humans the evidence basis for clinical use is extrapolated from animal data and small pilot studies No long-term safety data effects beyond 1216 weeks are not well characterised Variable results in human sleep trials some early human studies showed modest or inconsistent effects on sleep architecture compared to animal data, suggesting the translation may not be linear No FDA approval DSIP is not approved for any therapeutic use in the United States Stability concerns DSIP degrades relatively quickly in circulation

The absorbance at 450 nm was measured using a microplate reader (ELX800, BioTek Instruments Inc., Winooski, VT, USA) to determine cell viability relative to the control group

Taurine Supports electrolyte balance, cardiovascular function, and nervous system stability

Kpke M

In addition, patients with tophi are often at risk for uric acid-related kidney stones, since they may be over-producers of uric acid and have elevated 24-hour urinary uric acid