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Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators

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Mitochondrial dysfunction Disruption of mitochondrial defense mechanisms is mediated by the Parkin and PTEN-induced kinase 1 (PINK1) genes which are critical for mitophagy, a process that removes dysfunctional mitochondria from cells

Polyenylphosphatidylcholine (PPC) is a lipid carrier, often used to enhance the absorption and bioavailability of lipophilic compounds such as THC, which has low water solubility and poor enteric absorption

The signs recognizing opioid overdose are small, constricted pinpoint pupils, falling asleep or losing consciousness, slow, weak or no breathing, choking or gurgling sounds, limp body, cold and/or clammy skin, and discolored lips and nails (Centre for Disease Control and prevention, 2023)