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doi: 10.1038/s41698-021-00154-7 [DOI] [PMC free article] [PubMed] [Google Scholar] [132].Link A, Balaguer F, Shen Y, et al

Given the pleiotropic role SAM plays in methylation of diverse substrates, characterising the extent of SAM depletion and downstream perturbations following MAT2A/MAT1A inhibition (MATi) is critical for safety assessment

ScienceDirect , Pediatric Clinics of North America , vol

Functionally, PARN knockdown partially reversed the pro-tumorigenic effects of MAT2A overexpression, confirming that MAT2A regulates OS progression through the SRFPARN axis