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13 (4), e030233

27 However, when potential initiating events were investigated, the authors provided evidence that erastin inhibits system X c -, a Na + -independent cystine/glutamate antiporter responsible for cystine uptake into the cell, thereby promoting glutathione synthesis

Misfolded -synuclein can be released extracellularly, activating microglia and spreading pathogenic seeds or DAMPs to neighboring neurons, amplifying degeneration