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NCT04449029) 1485-C RECOMBINANT MOSAIC HBV CAPSID PARTICLES FOSTER ADAPTIVE IMMUNITY AGAINST THE MOST PREVALENT HBV GENOTYPES BY THERAPEUTIC VACCINATION Shubhankar Ambike 1 , Julia Sacherl 1 , Alexander Seidler 1 , Arie Geerlof 2 , Anna Kosinska 1,3 , Sophia Schreiber 1 , Frank Thiele 1 , Tanja Bauer 1,3 , Michael Nassal 4 , Anne Schtz 5 and Ulrike Protzer 3 , (1)Institute of Virology, School of Medicine, Technical University of Munich and Helmholtz Munich, Germany, (2)Institute of Structural Biolology, Helmholtz Munich and Technical University of Munich, Germany, (3)German Center for Infection Research, Munich Partner Site, Germany, (4)University Hospital Freiburg, Internal Medicine 2/Molecular Biology, University of Freiburg, Germany, (5)Faculty of Chemistry and Pharmacy, Ludwig Maximilian University of Munich, Germany Background: Hepatitis B virus (HBV)-specific B- and T-cell responses are key to cure HBV

519 The mechanism may be related to the interaction between NORAD and HUR, which promotes the stability of GPX4 mRNA and increase GPX4 levels

[21]Ashraf U, Kanu AS, et al

More studies about this topic would be important to eventually permit ultra-short scheduled of treatment to eradicate HCV infection: this could have paramount impact in the WHO program to eliminate HCV infection within 2030

Methods: Patients eligible for ASSERT were those of any age with ALGS, history of significant pruritus, and elevated serum bile acids