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The resulting increase in intracellular NAD+ availability activates sirtuins particularly SIRT1, which regulates insulin sensitivity, gluconeogenesis, cholesterol synthesis, and fatty acid oxidation, and SIRT3, which governs mitochondrial antioxidant defences and energy metabolism

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You may have heard about oxalate before in reference to kidney stones, but we know from research that oxalate can go virtually anywhere in the body, not just the kidney