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Appl Microbiol 117 , 286301 (2014)

If you are experiencing any of the symptoms associated with a deficiency, it is important to consult with a healthcare professional to determine the underlying cause and appropriate treatment plan

IV daratumumab was demonstrated in RRMM patients for monotherapy in the Phase III COLUMBA trial ( 3 prior lines) and in standard combination regimens in the Phase II PLEIADES trial ( 1 prior lines) [14]

5 Conclusions 1) This retrospective study provides the first in vivo evidence that DARA monotherapy, beyond its cytotoxic effects, modulates the secondary enzymatic functions of CD38 in MM, altering ADO and INO production and supporting a model of antibody-driven purinergic remodeling

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