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Characteristics of the included studies In total, 20 studies were selected after meeting the inclusion criteria, including ten animal studies and nine human studies

Advanced phase 1 studies provide additional information on the drug candidates pharmacological effects, metabolism, adverse effects linked to dose escalation, and potentially early effectiveness data

Macrophages control the bioavailability of vitamin D and vitamin D-regulated T cell responses

Bone, joint, and neuromuscular systems: Benefits in bone repair, spinal cord and peripheral nerve injury, and neuromuscular junction stabilization, including antispasticity and improved functional recovery in some animal models

Abbreviations Abu: -Aminobutyric acid ACC: 7-Amino-4-carbamoylmethylcoumarin DCM: Dichloromethane DMF: Dimethylformamide Et 3 N: Triethylamine HMPTA: Hexamethylphosphoramide MeCN: Acetonitrile Py-FLINT: Pyrene-based fluorescence intensity SAM: S -Adenosyl-l-methionine THF: Tetrahydrofuran Tle: tert -Leucine References Wang, C