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K., Cristofaro, V., & Sullivan, M

In head and neck squamous cell carcinoma, Gln levels increase following radiotherapy, and the Gln transporter SLC1A5 is upregulated

In this context, ROS-triggered TP53 activation heightens mitochondrial membrane permeability, leading to the release of pro-apoptotic factors from mitochondria

Oncologist 4 , 340341 (1999)

Inhibition of the mTOR pathway significantly reduces the inflammatory response in microglia, highlighting how cellular metabolic pathways, particularly the mTOR-HIF-1 pathway, can influence the functional phenotype of microglia (Cheng et al., 2014)