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Ongoing Research Phase 3 development programs (REDEFINE 1 and REDEFINE 2) are evaluating cagrilintidesemaglutide in obesity and type 2 diabetes populations, with cardiovascular and metabolic endpoints under active study

Additionally, preclinical tendon and ligament injury models show improved fibroblast recruitment and organized collagen deposition

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This is by far the best studied HGF antagonist and it was shown that it inhibits cell invasion and angiogenesis and in xenografts(Kuba et al., 2000)