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Notably, prophylactic administration of curcumin prior to A deposition demonstrates preventive potential for AD, possibly through facilitating A 42 clearance from the brain to peripheral circulation ( The therapeutic efficacy of curcumin in AD is considerably constrained by its limited ability to cross the blood-brain barrier

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Superoxide dismutases (SOD), catalase (CAT), and peroxidases using, e.g., Asc (ascorbate peroxidase, APX), GSH (glutathione peroxidase, GPX), or phenolic compounds as electron donors for peroxides reduction, are examples of ROS-detoxifying enzymes (Gechev et al