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201,202 Administration of the PRMT6 inhibitor EPZO20411 can inhibit the arginine methylation of chromatin condensation regulator 1 (RCC1), block the tyrosine kinase 2 (CK2) -PRMT6-RCC1 signaling axis, inhibit the proliferation of glioblastoma stem cells (GSCs) and increase their sensitivity to radiotherapy

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PMID: 22015471

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doi: 10.1038/s41591-019-0522-3 201 PaiJAHellmannMDSauterJLMattarMRizviHWooHJet al