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21 Alpha-lipoic acid is a multifunctional compound in its ability to serve as a direct scavenger of free radical species and to also help in the regeneration of endogenous antioxidants such as glutathione 21 Supplementing with vitamin C has been shown to increase glutathione levels by exerting their antioxidant action first, thus sparing glutathione

Under selenium deficiency, the protein expressions and/or activities of seleno-GPxs are decreased in a hierarchical order depending on their importance for cellular viability and functions (Table 1) [8, 25]

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