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de Lau et al., 2005

Zhang, Z., Liang, X., Zhang, Y., Xue, X., Ding, B., & Liu, H

Due to various interactions among genetic, economic, psycho-socio-cultural, behavioral, and pharmacological factors, the prevalence of obesity has risen globally, especially among certain racial/ethnic groups and individuals with lower educational attainment and income [14]

In fact, the fast, reversible, and specific interaction of OxyR with H 2 O 2 has been exploited in the design of HyPer, a genetically encoded biosensor that enables real-time imaging of peroxides in living cells, and which is based on the insertion of a yellow fluorescent protein into the sequence of OxyR [21, 22]

Release of pro-inflammatory mediators by microglia, the main effector cells of inflammation within the central nervous system (CNS), could be sufficient to cause AD pathology independently of other pathological events, such as deposition of the amyloid b protein (Ab) and neurofibrillary tangles (NFT) [4,5]