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The analysis revealed that the upregulated proteins in CHL were significantly enriched in serine-type endopeptidase activity ( p adjusted = 7.0E-11), heparin binding ( p adjusted = 1.3E-07), and complement binding ( p adjusted = 0.0009) (Supplementary Table S6

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These findings are not exclusive to animal studies, as a reduction in Complex I has also been observed in the tissues of human PD patients [58]

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