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It catalyzes the conversion of free long-chain fatty acids into acyl-CoA derivatives, facilitating their integration into cell membranes ( 2.1.4 Iron-responsive element-binding protein 2 Other molecules involved in lipid and iron metabolism also regulate ferroptosis, including iron-responsive element-binding protein 2 (IRP2) ( 2.2 Organelle-specific regulation of ferroptosis Organelle interactions are fundamental to the regulation of ferroptosis and include various cellular compartments such as mitochondria and the endoplasmic reticulum (ER), which work in conjunction with lipid metabolic pathways ( Figure 2 )

The choice of administration route often depends on the intended therapeutic target and whether localized or systemic effects are desired

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This likely applies to several other necrotic hepatic diseases involving BCL-2 family members, such as Thioacetamide intoxication or ischemia/reperfusion injury

Phytomedicine : international journal of phytotherapy and phytopharmacology