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In vivo , in an AIA rat model, the circulation half-life of HA@M@PB@SINNPs at the site of arthritis reached 6.51 h, which is eight times that of free sinomenine hydrochloride (SH), significantly enhancing drug accumulation

The secoiridoid part is characterized by an open-ring configuration, which plays a pivotal role in its distinct chemical and biological behaviors

doi: 10.1038/s41366-020-0615-6 125 FjeldborgKChristiansenTBennetzenMJ MllerHPedersenSBRichelsenB

AMH (anti-Mllerian hormone) reflects ovarian reserve but can be altered by metabolic stress

The Arg/N-degron pathway targets transcription factors and regulates specific genes