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Compared to NZW mice, the expression of the transferrin receptor 24p3R in the renal tubules of NZB/W mice was reduced, while transferrin expression and ferritin expression were increased, consistent with increased iron accumulation and compensatory downregulation of uptake pathways

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The pharmacokinetics were compatible with a two-compartment model with a first-order distribution and elimination rate, and pharmacokinetic parameters were not different between the two doses, except for the elimination half-life

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