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NAD+ is a critical coenzyme involved in energy production and various cellular processes such as DNA repair, cellular energy and mitochondria health

Interestingly, there have been mixed reports on the impact of HRT on IGF-1 concentrations in post-menopausal women, confounded by the different formulations (estrogen or estrogen plus progestin) and modes of delivery with oral estradiol decreasing IGF-1 concentrations and the androgenic synthetic progestin causing an increase ( FIGURE 1 Androgens Although androgens are known to stimulate the GH/IGF-1 axis in men there is scant information in the literature about the impact of androgens on the GH/IGF-1 axis in women, which may be a significant factor especially during the post-menopausal period

The study found that short term subcutaneous administration of GHRH to healthy old men reverses age-related decreases in GH and IGF-I [6]

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Nowadays, peptides are one such therapy among gymgoers