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The previously identified and accepted pathways of communication include the nervous system via the vagus nerve, the immune system, and enteroendocrine signaling pathways [159]

Most published work is in rodent models

Chronic inflammation often involves an overabundance of M1 macrophages

In addition, combination strategies that enhance doxycycline activity against biofilm-forming pathogens, such as co-administration with N-acetyl-L-cysteine, have shown promising in vitro results (56), and could be explored in future formulations or dosing regimens

BPC-157 demonstrates neuroprotective effects across traumatic brain injury, stroke, spinal cord injury, and peripheral nerve damage in animal models