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10.1152/ajpheart.00697.2008 149 MichielsC

Pharmacological modulation of ferroptosis has emerged as a promising therapeutic approach for cancer and ischemia-reperfusion injury (IRI) in various preclinical rat models (94,95)

Graber TW, Yee AS, Baker FJ

Catalytic Residues Roles Chemical Components aromatic unimolecular elimination by the conjugate base, hydride transfer, aromatic bimolecular nucleophilic addition, cofactor used, intermediate formation, overall product formed, overall reactant used, rate-determining step, bimolecular nucleophilic substitution, enzyme-substrate complex formation, enzyme-substrate complex cleavage, intermediate collapse, intermediate terminated, native state of cofactor regenerated, proton transfer, native state of enzyme regenerated References Deponte M (2013), Biochim Biophys Acta , 1830 , 3217-3266