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Once the LT4 has crossed the intestinal epithelium and reached the circulation, it is almost entirely (~99.9%) bound to plasma proteins (mainly albumin, thyroxine-binding globulin (TBG), transthyretin, and high-density lipoprotein)

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In controlled research environments, SS-31 is commonly investigated for its role in mitochondrial bioenergetics, cellular stress response, and peptide-mediated regulation of mitochondrial function

For example, if the glutaredoxin sulfur atom in Grx(SSR) species was accessible for a productive reaction with GSH, one would not expect to trap such species by monothiol glutaredoxin mutants 8385