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4.4.4 Methionine Methionine can induce M1 macrophage polarization, which was linked to a pro-inflammatory state of macrophages with increased TNF production and iNOS activity, alterations in extracellular nucleotide metabolism, and an increased hydrolysis of ATP and ADP ( 4.4.5 Phenylalanine Phenylalanine has been proposed to attenuate the inflammatory profile of M1 macrophages by reprogramming the transcriptomic and metabolic profiles, thereby augmenting oxidative phosphorylation in M1 macrophages