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Obesity and diabetes are increasingly recognized as risk factors for PDAC, not only because of the remodelling of the tumour microenvironment but also because of their effects on systemic metabolism [249, 250]

Silymarin refers to the extract from the seeds of the plant Silybum marianum, also called milk thistle. It has been used for over 2,000 years

Riluzole was the first FDA-approved compound for ALS (in 1995), which inhibits glutamatergic neurotransmission and thus inhibits excitotoxicity (Dharmadasa and Kiernan, 2018

10.1016/j.atherosclerosis.2018.01.031 133

As well as general chaperone activity, PDI family members possess oxidoreductase activity, which mediates the formation of protein disulfide bonds by cysteine residues located within its active site