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However, the efficacy, stability, and safety of the agents, as well as whether they could disturb local or systemic energy metabolism should be considered comprehensively in future clinical uses

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In this study, we found that a combination of theophylline, palmitoylethanolamide, hypoxanthine, and CDH5 provides a high diagnostic accuracy

Ethics declarations Ethics approval and consent to participate The animal protocol was approved and all the experimental procedures were supervised by the Ethics Committee of the Third Military Medical University (SYXK20170002)