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NAD+ is a vital coenzyme involved in energy metabolism and DNA repair

However, the clinical study did not acomplish the main goal of a Phase IIb study by not showing differences over the placebo treatment under FDA current guidelines 4

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Accordingly, we advocate that preclinical pipelines include: (i) paired SCC and AC in vitro clonogenic and DNA-damage assays with hydrogel-released radiosensitizers