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Furthermore, ZZ-A1ATD patients exhibit altered levels of reactive species: a decrease in superoxide (O2-) and an increase in hydrogen peroxide (H2O2), peroxynitrite (ONOO-), and nitric oxide (NO) are observed

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doi: 10.1093/annonc/mdp354

Collectively, these experimental studies demonstrate that biodegradable polymeric nanomaterials for drug delivery of TAC hold significant potential in enhancing clinical therapeutic effects

The convergence of metabolic overload, mitochondrial fragmentation, and impaired antioxidant regulation creates a vicious cycle of ROS generation and mitochondrial dysfunction, contributing to apoptosis, inflammation, and neovascularization in the diabetic retina